Endocrine Abstracts

Introduction: Denosumab reduces bone resorption, increases BMD, and reduces fracture risk. Denosumab discontinuation (DD) induces an increase of B-crosslaps above baseline values for two years, and a decrease of BMD values. This rebound effect is associated with spontaneous clinical vertebral fractures (SCVF) in close to 15% of patients considering a follow-up of 2 years without taking another osteoporosis treatment. Prescribing a bisphosphonate or SERMs at DD would prevent th...

Denosumab discontinuation (DD) induces an increase of B-crosslaps above baseline values for two years, and a decrease of BMD values. This rebound effect is associated with spontaneous clinical vertebral fractures (SCVF) in close to 15% of patients considering a follow-up of 2 years without taking another osteoporosis treatment. We report the clinical characteristics of 31 patients evaluated at our center from July 2015 to January 2018.Results: Thirty wom...

Introduction: Hormonal replacement therapy (HRT) increases bone mineral density (BMD). Controversy exists regarding residual effect after withdrawal. We aimed to explore the effect of HRT and HRT withdrawal on: i) BMD and bone microarchitecture assessed by trabecular bone score (TBS); ii) fat (FMI), lean (LMI) and appendicular lean (ALMI) mass indexes.Methods: The OsteoLaus Cohort assessed 1500 women (50–80 years) for BMD, TBS, total energy expendit...

Background: We previously showed that menopausal hormone therapy (MHT) favorably affects both bone density and microarchitecture with persistent benefit after its withdrawal (1). Looking for indirect factors contributing to bone effects, we investigated the relation between MHT and changes on fat and lean (muscular) tissue. Existing results on MHT and body composition are conflicting and large cohort studies are lacking.Material and methods: The OsteoLau...

Introduction: Aging is associated with a decrease in muscle and bone mass, and a gain in fat mass. Similar changes are more pronounced in hypercortisolism. We previously demonstrated that high 8 PM salivary cortisol is independently associated with increased prevalence of radiologic vertebral fractures. We wanted to determine whether salivary cortisol circadian rhythm played also a role on body composition.Material and Methods: Cross-sectional study incl...